
The region of Dubrovnik-Neretva was originally inhabited by Illyrian tribes, primarily the Ardiaeans and Pleraei, who fiercely resisted Roman expansion. The First Illyrian War (229–228 BC) saw Roman legions defeat Queen Teuta's forces along the Dalmatian coast. Greek colonies like Epidaurum (modern Cavtat) were established as early as the 6th century BC, creating tensions with inland Illyrian tribes. The Great Illyrian Revolt (6–9 AD) under Bato of the Daesitiates involved the region in a massive uprising that took three years and 15 Roman legions to suppress, devastating the local population.
During the 6th and 7th centuries, Slavic and Avar tribes swept into the Balkans, destroying the Roman city of Epidaurum and settling the Neretva river delta. The Neretvani (Narentines) became notorious pirates who controlled the Adriatic between the Neretva and Cetina rivers. They repeatedly fought the Republic of Venice, most notably defeating the Venetian fleet in 948 AD. For centuries the Neretvani resisted Christianization and Venetian domination, maintaining their pagan traditions and maritime raiding culture.
The Republic of Ragusa, centered in Dubrovnik, emerged as a maritime power after the Fourth Crusade by skillfully navigating between larger powers. In 1358, the Treaty of Zadar freed Ragusa from Venetian suzerainty under Hungarian protection. The Republic paid an annual tribute to the Ottoman Empire from 1458 to maintain its autonomy, a pragmatic policy that preserved its independence for over 450 years. The Ragusan navy defended against numerous Ottoman attacks, including the 1571 Battle of Lepanto where Ragusan ships fought alongside the Holy League.
In 1808, Napoleon Bonaparte's forces dissolved the Republic of Ragusa, ending centuries of independence. The French occupation brought administrative reforms but also heavy taxation and conscription. Local resistance emerged, with Ragusan rebels fighting French garrisons. In 1813, a coalition of British and Austrian forces, supported by local militias, expelled the French. However, the Congress of Vienna in 1815 awarded the entire region to the Austrian Empire, beginning a century of Austro-Hungarian rule that suppressed Croatian national aspirations.
During World War II, the Dubrovnik-Neretva region was occupied by Fascist Italy from 1941 to 1943, then by Nazi Germany after the Italian armistice. The Ustaše regime targeted ethnic Serbs, Jews, and Roma for genocide, with massacres reported in the Neretva valley. The region became a battleground between the Yugoslav Partisans and Axis forces, with the Neretva river valley serving as the site of the famous Battle of the Neretva in 1943, where Tito's Partisans broke through German and Ustaše encirclement. Mass reprisals against civilians were common, with hundreds executed in the Konavle region.
In 1991, following Croatia's declaration of independence, the Yugoslav People's Army (JNA) and Montenegrin reservists attacked the Dubrovnik-Neretva region in what became known as the Siege of Dubrovnik. From October 1991 to May 1992, the JNA bombarded the UNESCO World Heritage Old Town, destroying or damaging over 68% of its buildings. Civilian casualties exceeded 200 killed, with thousands displaced. The siege became an international symbol of cultural destruction and war crimes. The region also saw fierce fighting in the Neretva valley around Metković and the Pelješac peninsula, culminating in Operation Tiger in July 1992, which forced the JNA to withdraw and ended the siege.